PANCREAS

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EPI stands for Exocrine Pancreatic Insufficiency—a condition in which the body does not have sầu the right amount of pancreatic enzymes to lớn properly break down food.


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EPI stands for Exocrine Pancreatic Insufficiency—a condition in which the body does not have sầu the right amount of pancreatic enzymes to lớn properly break down food.


To better understand EPI, it helps lớn know what the pancreas does.

Located in the center of the abdomen, the pancreas has 2 important functions:

Endocrine function

makes insulin, a hormone that helps the body toàn thân process the sugar we eat.

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Exocrine function

makes enzymes khổng lồ help digest food so the toàn thân can absorb it.

In people with EPI, it’s the exocrine function of the pancreas that is affected.

When you have EPI, your toàn thân doesn’t have sầu enough of the pancreatic enzymes needed khổng lồ break down the food you eat. As a result, EPI affects the way your body toàn thân digests food, causes unpleasant gastrointestinal (GI) symptoms, và may prsự kiện you from getting the necessary nutrition from the foods you eat.


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Endocrine cells 3D 2% of the pancreas & secrete insulin inlớn the bloodstream



When you have sầu EPI, your body doesn’t have sầu enough of the pancreatic enzymes needed to lớn break down the food you eat. As a result, EPI affects the way your body digests food, causes unpleasant gastrointestinal (GI) symptoms, và may prevent you from getting the necessary nutrition from the foods you eat.


Digestion starts in your mouth

When you chew food, the enzymes in your saliva begin the process of digestion.


Digestion starts in your mouth

When you chew food, the enzymes in your saliva begin the process of digestion.


Food travels down lớn the stomach

Food mixes with stomach acid và enzymes that further break it down.


Food travels down to lớn the stomach

Food mixes with stomach acid & enzymes that further break it down.


EPI starts with the pancreas

Next, the pancreas releases enzymes that mix with the food as it enters the small intestine. If you have EPI, there is a problem with these pancreatic enzymes.


EPI starts with the pancreas

Next, the pancreas releases enzymes that set with the food as it enters the small intestine. If you have EPI, there is a problem with these pancreatic enzymes.

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Maldigestion

With EPI, food doesn"t get broken down the way it should, so your toàn thân isn"t able khổng lồ digest & absorb nutrients properly.


Maldigestion

With EPI, food doesn"t get broken down the way it should, so your body isn"t able lớn digest và absorb nutrients properly.


The symptoms of EPI may be similar khổng lồ other gastrointestinal disorders, which can make it a difficult condition khổng lồ diagnose. Only your doctor can determine if EPI is the cause of your symptoms.

Use our symptom checker khổng lồ identify your symptoms & help start a discussion with your doctor.


Sources: 1. Ferrone M, Raimonvày M, Scolapio JS. Pancreatic enzyme pharmacotherapy. Pharmacotherapy. 2007;27(6):910-9đôi mươi. 2. Molimãng cầu PE. Endocrine pancreas. Endocrine Physiology. 4th ed. New York, NY: McGraw-Hill; 2013: 163-186. 3. Gorelichồng FS, Jamieson JD. Structure-function relations in the pancreatic acinar cell. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. 4th ed. Burlington, MA: Elsevier Academic Press; 2006:1313-1335. 4. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present & future. Clin Exp Gastroenterol. 2011;4:55-64. 5. Hasler WL, Owyang C. Chapter 290, Approach khổng lồ the patient with gastrointestinal disease. In: Longo DL, Fauci AS, Kasper DL, et al, eds. Harrison"s Principles of Internal Medicine. 18th ed. Thành Phố New York, NY: McGraw-Hill; 2012. 6. Domínguez-Muñoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. Curr Gastroenterol Rep. 2007;9(2):116-122. 7. Alkaade S, Vareedayah AA. A primer on exocrine pancreatic insufficiency, fat malabsorption, và fatty acid abnormalities. Am J Manag Care. 2017;23(suppl 12):S203-S209.
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